29 de novembro de 2020

ASSOCIATIONS STUDYO OF DOPAMIINED D3 AND D3 RECEPTOR GENE POLYMORPHISMS WITTH COCAINE DEPENDENCE

26 de novembro de 20131min

Acesse: Cocaine.pdf

ASSOCIATIONS STUDYO OF DOPAMIINED  D3 AND D3 RECEPTOR GENE POLYMORPHISMS WITTH COCAINE DEPENDENCE

Guilherme Messas, Ivanor MeiraLima; Marília Turch;Olavo Franco; AdautoCastelo Ronaldo Laranjeira and Homero Vallada

Family and twin studies suggest a substantial genetic component in the vulnerability of individuals to become dependent after exposed to cocaine (Merikangas et al, 1998; Bierut et al, 1998; Kendler & Prescott, 1998). The reinforcing properties of cocaine are related with the dopaminergic system, and in particular the dopamine receptors have been implicated in “reward” mechanisms (Comings & Blum, 2000; Noble EP, 2000). The effect of neurotransmitter interaction at the mesolimbic brain region induces a “reward” when dopamine is released from the neuron at the nucleus accumbens and interacts with a dopamine receptor. A dopaminergic mechanism may therefore be responsible for interindividual differences in the susceptibility to developing cocaine dependence. In the context of a molecular genetic approach to this issue, candidate genes related to this vulnerability include the dopamine receptor gene


Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.



Newsletter