Neuropsychological assessment of current and past crack cocaine users.

PubMed
De Oliveira LG, Barroso LP, Silveira CM, Sanchez ZV, De Carvalho Ponce J, Vaz LJ, Nappo SA.
Department of Psychiatry, Medical School, Universidade de São Paulo (USP), São Paulo (SP), Brazil. lucio@cisa.org.br
BACKGROUND: Cognitive changes due to crack cocaine consumption remain unclear.
METHODS: For clarification, 55 subjects were assigned to three groups: control group, crack cocaine current users, and ex-users. Participants were submitted to Mini-Mental State Examination (MMSE) and tasks evaluating executive functioning and verbal memory. Mood state was also measured. Intergroup comparisons were carried out.
RESULTS: Control group performance on the MMSE was better than that of users and ex-users. Verbal memory performance for logical memory of users was impaired. Ex-users scored lower on DSST and Trail Making Test (Part B).
CONCLUSION: Chronic crack cocaine use seems to disrupt general cognitive functioning (MMSE), verbal memory, and attentional resources, but findings suggest that some of these effects could be reversed by abstinence.
PMID: 20001290 [PubMed – in process]