Use of N-acetylcysteine in cannabis-dependent adolescents.

9 de fevereiro de 20131min

Jeremy Bradley, MD and Divya Gupta, MD

Clinical Question: Can N-acetylcysteine use in conjunction with cessation therapy and contingency management improve successful cannabis cessation in cannabis-dependent adolescents?

Clinical Bottom Line

  1. In a double-blinded randomized controlled trial of cannabis dependent adolescents , findings support use of N-acetylcysteine (NAC) along with psychosocial treatment yield a positive primary cessation outcome.


  2. NAC treatment group had greater than twice the odds compared with the placebo group of having negative urine cannabinoid tests while on treatment.

  3. Secondary abstinence outcomes favored the NAC treatment group but were not statistically significant.

  4. NAC was well tolerated with minimal adverse effects.

pdf NACforCannabisDependence.pdf

Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.