Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T

29 de abril de 20143min0

Journal of Cardiovascular Magnetic Resonance 2014, 16:26
Alicia M Maceira (amaceira@eresa.com)
Carmen Ripoll (cripoll@comv.es)
Juan Cosin-Sales (jcosinsales@gmail.com)
Begoña Igual (bigual@eresa.com)
Mirella Gavilán (mgavilan@eresa.com)
Vicente Belloch (vbelloch@eresa.com)
Dudley J Pennell (d.pennell@ic.ac.uk)

Cocaine is a highly addictive sympathomimetic drug with potentially lethal effects [1,2]. The annual prevalence of cocaine use is 0.3% to 0.5% of the world population aged 15-64 [3], corresponding to roughly 18 million people. Standardised mortality ratios suggest that mortality is 4-8 times higher among cocaine users than age and gender peers in the general population [4]. Cocaine cardiotoxicity appears multifactorial through several mechanisms involving the development of ischemia and infarction [5], ventricular hypertrophy [6], systolic dysfunction[7], arrhythmias [8], endocarditis [9], and aortic pathology [10]. Cocaine is usually consumed along with other substances, mainly ethanol and tobacco, which can exacer bate the deleterious effects of cocaine [11]


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A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.


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