16 de outubro de 2021

Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T

29 de abril de 20143min35
2c73e13b1cabeb4528615999425c9f5d

Journal of Cardiovascular Magnetic Resonance 2014, 16:26
doi:10.1186/1532-429X-16-26
Alicia M Maceira (amaceira@eresa.com)
Carmen Ripoll (cripoll@comv.es)
Juan Cosin-Sales (jcosinsales@gmail.com)
Begoña Igual (bigual@eresa.com)
Mirella Gavilán (mgavilan@eresa.com)
Vicente Belloch (vbelloch@eresa.com)
Dudley J Pennell (d.pennell@ic.ac.uk)

 
 
Cocaine is a highly addictive sympathomimetic drug with potentially lethal effects [1,2]. The annual prevalence of cocaine use is 0.3% to 0.5% of the world population aged 15-64 [3], corresponding to roughly 18 million people. Standardised mortality ratios suggest that mortality is 4-8 times higher among cocaine users than age and gender peers in the general population [4]. Cocaine cardiotoxicity appears multifactorial through several mechanisms involving the development of ischemia and infarction [5], ventricular hypertrophy [6], systolic dysfunction[7], arrhythmias [8], endocarditis [9], and aortic pathology [10]. Cocaine is usually consumed along with other substances, mainly ethanol and tobacco, which can exacer bate the deleterious effects of cocaine [11]
 

 
 
 


Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.



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