Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study

14 de setembro de 20133min3


Research Article

Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study

  1. Janna Cousijn1,2,3,4,*,
  2. Reinout W. Wiers1,
  3. K. Richard Ridderinkhof5,6,
  4. Wim van den Brink2,3,
  5. Dick J. Veltman2,7,
  6. Anna E. Goudriaan2,3,8

Article first published online: 3 SEP 2013

DOI: 10.1002/hbm.22342

Copyright © 2013 Wiley Periodicals, Inc.


Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal of the current functional magnetic resonance imaging study was to assess the predictive power of working-memory network function for future cannabis use and cannabis-related problem severity in heavy cannabis users. Tensor independent component analysis was used to investigate differences in working-memory network function between 32 heavy cannabis users and 41 nonusing controls during an N-back working-memory task. In addition, associations were examined between working-memory network function and cannabis use and problem severity at baseline and at 6-month follow-up. Behavioral performance and working-memory network function did not significantly differ between heavy cannabis users and controls. However, among heavy cannabis users, individual differences in working-memory network response had an independent effect on change in weekly cannabis use 6 months later (ΔR2 = 0.11, P = 0.006, f2 = 0.37) beyond baseline cannabis use (ΔR2 = 0.41) and a behavioral measure of approach bias (ΔR2 = 0.18): a stronger network response during the N-back task was related to an increase in weekly cannabis use. These findings imply that heavy cannabis users requiring greater effort to accurately complete an N-back working-memory task have a higher probability of escalating cannabis use. Working-memory network function may be a biomarker for the prediction of course and treatment outcome in cannabis users. Hum Brain Mapp, 2013. © 2013 Wiley Periodicals, Inc.

acesse: http://onlinelibrary.wiley.com/doi/10.1002/hbm.22342/abstract;jsessionid=13279FEEC8497D112867BC2887D02925.d01t01?deniedAccessCustomisedMessage=&userIsAuthenticated=false

Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.


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