Decision-Making Deficits Linked to Real-life Social Dysfunction in Crack Cocaine-Dependent Individuals.
Am J Addict. 2011 Jan;20(1):78-86. doi: 10.1111/j.1521-0391.2010.00097.x. Epub 2010 Nov 12.
Cunha PJ, Bechara A, de Andrade AG, Nicastri S.
Interdisciplinary Group of Studies on Alcohol and Drugs, Institute and Department of Psychiatry, University of São Paulo College of Medicine, São Paulo, Brazil Equilibrium Program, School of Medicine, Department and Institute of Psychiatry, University of São Paulo, São Paulo, Brazil Department of Psychology and the Brain and Creativity Institute, University of Southern California, Los Angeles, California Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa.
Crack cocaine-dependent individuals (CCDI) present abnormalities in both social adjustment and decision making, but few studies have examined this association. This study investigated cognitive and social performance of 30 subjects (CCDI × controls); CCDI were abstinent for 2 weeks. We used the Social Adjustment Scale (SAS), Wisconsin Card Sorting Test (WCST), and Iowa Gambling Task (IGT). Disadvantageous choices on the IGT were associated with higher levels of social dysfunction in CCDI, suggesting the ecological validity of the IGT. Social dysfunction and decision making may be linked to the same underlying prefrontal dysfunction, but the nature of this association should be further investigated. (Am J Addict 2010;00: 1-9).
© American Academy of Addiction Psychiatry.
PMID: 21175924 [PubMed – in process]