Reviews and Overviews – Mechanisms of Psychiatric Illness
Mood and substance use disorders com- monly co-occur, yet there is little evidence- based research to guide the pharmaco- logic management of these comorbid disorders. The authors review the existing empirical findings, some of which may call into question current clinical pharmaco- therapy practices for treating co-occurring mood and substance use disorders. The authors also highlight knowledge gaps that can serve as a basis for future research. The specific mood disorders reviewed are bi- polar and major depressive disorders (either one co-occurring with a substance use disorder).