18 de outubro de 2021

Antipsychotic drugs in cocaine dependence: A systematic review and meta-analysis.

3 de fevereiro de 20133min29


J Subst Abuse Treat. 2013 Jan 25. pii: S0740-5472(12)00474-6. doi: 10.1016/j.jsat.2012.12.013.

Human Pharmacology Unit, Hospital del Mar Medical Research Institute-IMIM, UCICEC-CAIBER, Parc de Salut MAR, 08003 Barcelona, Spain; Universitat Autònoma de Barcelona (Department of Pharmacology, Therapeutics and Toxicology and Department of Psychiatry), 08193 Bellaterra (Cerdanyola del Vallès), Spain.


A systematic review and meta-analysis to evaluate the efficacy of antipsychotic drugs in subjects with cocaine dependence is presented. Twelve randomized, double-blind, placebo-controlled clinical trials involving 681 patients were included. Five outcome measures were evaluated: number of dropouts, cocaine use assessed by means of urine benzoylecgonine tests, self-reported cocaine use, craving and Addiction Severity Index. On average, 48% of the enrolled participants were lost to follow-up. In comparison to placebo, antipsychotics did not significantly reduce cocaine use (WMD=0.01, 95%CI=-0.12 to 0.13) or improve retention in treatment (RR 0.91, 95%CI=0.82-1.02). Risperidone reduced slightly dropouts in comparison to placebo (RR=0.87; 95%CI=0.79-0.97). To date there is insufficient evidence to justify the use of antipsychotic drugs for cocaine dependence.

Copyright © 2012. Published by Elsevier Inc.

[PubMed – as supplied by publisher]

Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.