27 de outubro de 2020

Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk

17 de abril de 20152min
  1. Phillipp Hartmann1,
  2. Caroline T. Seebauer1 and
  3. Bernd Schnabl1,2,*

Article first published online: 14 APR 2015

DOI: 10.1111/acer.12704

http://onlinelibrary.wiley.com/doi/10.1111/acer.12704/abstract?campaign=woletoc&dmmsmid=93331&dmmspid=21805070&dmmsuid=2433551

Keywords:

  • Alcoholic Liver Disease;
  • Microbiome;
  • Bacterial Translocation;
  • Intestinal Bacterial Dysbiosis;
  • Metabolome

Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. Alcoholic fatty liver disease can progress to steatohepatitis, alcoholic hepatitis, fibrosis, and cirrhosis. Patients with alcohol abuse show quantitative and qualitative changes in the composition of the intestinal microbiome. Furthermore, patients with ALD have increased intestinal permeability and elevated systemic levels of gut-derived microbial products. Maintaining eubiosis, stabilizing the mucosal gut barrier, or preventing cellular responses to microbial products protect from experimental ALD. Therefore, intestinal dysbiosis and pathological bacterial translocation appear fundamental for the pathogenesis of ALD. This review highlights causes for intestinal dysbiosis and pathological bacterial translocation, their relationship, and consequences for ALD. We also discuss how the liver affects the intestinal microbiota.


Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.



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