28 de março de 2024

Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence

13 de novembro de 20132min0

 Acesse:    Cocaina Messas 2005 PG.pdf 

Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence
Guilherme Messasa, Ivanor Meira-Lima, Marı´lia Turchi, Olavo Franco,
Camila Guindalini, Adauto Castelo, Ronaldo Laranjeira and Homero Vallada

Psychiatr Genet 15:171–174 c 2005 Lippincott Williams & Wilkins.
Genetic factors play a role in the vulnerability to cocaine dependence. The reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. The present study examines the role of the variants TaqI A of the dopamine D2 receptor gene and BalI of the dopamine D3 receptor gene in a Brazilian sample consisting of 730 cocaine dependents and 782 healthy controls. The studied polymorphisms did not show any difference in allelic frequencies or genotypic distribution between the groups. Our data do not support a role for the
dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.


Sobre a UNIAD

A Unidade de Pesquisa em álcool e Drogas (UNIAD) foi fundada em 1994 pelo Prof. Dr. Ronaldo Laranjeira e John Dunn, recém-chegados da Inglaterra. A criação contou, na época, com o apoio do Departamento de Psiquiatria da UNIFESP. Inicialmente (1994-1996) funcionou dentro do Complexo Hospital São Paulo, com o objetivo de atender funcionários dependentes.



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